FREE RADICAL PRODUCTION INDUCED BY NITROIMIDAZOLE COMPOUNDS LEAD TO CELL DEATH IN LEISHMANIA INFANTUM AMASTIGOTES

Free Radical Production Induced by Nitroimidazole Compounds Lead to Cell Death in Leishmania infantum Amastigotes

Leishmania infantum is the vector-borne trypanosomatid parasite causing visceral leishmaniasis in the Mediterranean basin.This neglected tropical disease is treated with a limited number of obsolete drugs that are not exempt from adverse effects and whose overuse has promoted the emergence of resistant pathogens.In the search for novel antitrypanos

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Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling

Lactobacillus plantarum (LP) has been shown to exhibit protective effects on intestinal barrier function click here in septic rats, although the regulatory mechanism has not been established.We determined whether LP imparts such protective effects in a lipopolysaccharide (LPS)-induced Caco2 cell monolayer model and whether cAMP-PKA signaling is the

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